DNA, Stress, And Everyday Health (EP 90)
Most of us still think about DNA like a CSI tool, but Len May breaks down how genetics, epigenetics, and AI can actually guide everyday decisions about stress, inflammation, and long‑term health. We talk about DNA as your personal GPS, why your lifestyle can flip genetic “switches” on or off, and how his journey from ADD and cannabis to EndoDNA connects the science to real life.
I sit down with Len May, co‑founder and CEO of EndoDNA, to unpack what our genetics are really telling us about how we eat, handle stress, and respond to our environment. Len explains DNA as an “encoding” that sets up predispositions, while epigenetics, lifestyle, and neurochemistry decide which switches actually get turned on—impacting everything from inflammation and gut issues to cognitive decline.
We also touch on how AI is now helping doctors interpret this data, moving from our current “sick care” model to something closer to true preventive healthcare. Len shares examples like the APOE4 gene and Alzheimer’s risk, cortisol’s impact on pain and gut health, and how simple choices around food, supplementation, and therapies can help keep your body closer to balance. This first part ends with a teaser into Len’s personal story—immigrating from Lithuania, getting labeled with ADD, discovering cannabis, and eventually building EndoDNA as a bridge between plant medicine and precision genetics.
Chapters:
- 00:21 Introduction to Our Biology
- 02:51 The Role of Lifestyle and Environment
- 09:15 Understanding Genetic Predispositions
- 10:24 Health and DNA: Prevention Strategies
- 18:29 Len's Journey to Genetics
- 26:13 The Intersection of Cannabis and Genetics
- 30:26 Conclusion and Next Steps
Guest: Len May, EndoDNA
- Website: https://shop.endodna.com
- Website: https://www.lenmaycoaching.com/
- LinkedIn: https://www.linkedin.com/in/lenmay
Companies / Vendors / Products Mentioned
- 23andMe: https://www.23andme.com
- Ancestry.com: https://www.ancestry.com
- Tower Records: https://www.towerrecords.com
- Rand McNally: https://www.randmcnally.com
- Heritage Cannabis Holdings: https://heritagecann.com
=== About the Unhealthy Podcast
Hosted by Marvin Bee (Uncle Marv), the Unhealthy Podcast dives into real conversations about health, wellness, and everyday habits that impact how we live, work, and age. From nutrition myths to stress management and tech-life balance, Uncle Marv brings humor, insight, and honesty to every episode.
- Visit our website: https://www.unhealthypodcast.com/
- Connect on Facebook: https://www.facebook.com/iamunclemarv
- Connect on LinkedIn: https://www.linkedin.com/in/marvinbee/
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Len May is a polymath, global speaker, and recognized authority in personalized medicine, genetics, and human optimization. As CEO and Co-Founder of EndoDNA, he’s pioneering a new era of precision health, using genomics and AI to help people understand how their unique biology shapes their wellness, focus, and fulfillment.
Over the last 25 years, Len has built and exited multiple multi-million-dollar ventures while leading EndoDNA’s breakthrough work in genetic wellness and personalized medicine.
The company’s patented DNA→Protocol platform now powers personalized protocols across hormone health, longevity, cognition, and nutrition, serving thousands of patients and practitioners worldwide.
His upcoming book, Jack of All Trades and Master of Some, explores how ADD, curiosity, and diverse talents can become superpowers for mastery and meaning.
As host of the popular podcast Everything Is Personal, Len brings these conversations to life, interviewing leading thinkers in science, wellness, and culture.
